Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain
نویسندگان
چکیده
منابع مشابه
High mobility group box 1 protein as a late-acting mediator of acute lung inflammation.
Acute inflammatory lung injury is often a delayed complication of critical illness and is associated with increased mortality. High mobility group box 1 (HMGB1) protein, in addition to its role as a transcriptional regulator factor, has been identified as a late mediator of endotoxin lethality and might be also involved in the development and progression of acute lung injury. HMGB1 protein itse...
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High-mobility group box protein 1 (HMGB1) is a non-histone nuclear protein that has a dual function. Inside the cell, HMGB1 binds DNA, regulating transcription and determining chromosomal architecture. Outside the cell, HMGB1 can serve as an alarmin to activate the innate system and mediate a wide range of physiological and pathological responses. To function as an alarmin, HMGB1 translocates f...
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High mobility group box 1(HMGB1), originally described as a DNA-binding protein, can also be released extracellularly and functions as a late mediator of inflammatory responses. Although recent reports indicated that the receptor for advanced glycation endproducts (RAGE), as well as Toll-like receptors (TLR2 and TLR4), were involved in cellular activation by HMGB1, there has been little evidenc...
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High-mobility group box 1 (HMGB1; also known as amphoterin) protein was identified more than 30 years ago as a non-chromosomal nuclear protein that maintains the nucleosome structure and regulates gene transcription. HMGB1 is highly conserved among species, has over 98% identity among all mammals, and is ubiquitously expressed in almost all types of cells. HMGB1-deficient mice are viable but di...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2014
ISSN: 1076-1551,1528-3658
DOI: 10.2119/molmed.2014.00176